Interaction of background genetic risk, psychotropic medications, and primary angle closure glaucoma in the UK Biobank.

ABSTRACT:

Background/aims

Psychotropic medications have been reported as a risk factor for angle closure disease. However, the interaction between background genetic risk for primary angle closure glaucoma (PACG) and susceptibility to angle closure disease among psychotropic medication users has not been investigated. Here we demonstrate the utility of a genome-wide polygenic risk score (PRS) in identifying and risk-stratifying subjects with PACG and investigate the association between PACG genetic burden and exposure to psychotropic medications on prevalent angle closure.

Methods

This analysis used the UK Biobank dataset, a prospective cohort study of 502,506 UK residents. We constructed a PACG PRS for participants using genome-wide association study summary statistics from a multiet

SUBMITTER: Sekimitsu S 

PROVIDER: S-EPMC9239437 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature