Leishmania braziliensis causing human disease in Northeast Brazil presents loci with genotypes in long-term equilibrium.

ABSTRACT:

Background

Leishmaniases are neglected tropical diseases that inflict great burden to poor areas of the globe. Intense research has aimed to identify parasite genetic signatures predictive of infection outcomes. Consistency of diagnostic tools based on these markers would greatly benefit from accurate understanding of Leishmania spp. population genetics. We explored two chromosomal loci to characterize a population of L. braziliensis causing human disease in Northeast Brazil.

Methodology/principal findings

Two temporally distinct samples of L. braziliensis were obtained from patients attending the leishmaniasis clinic at the village of Corte de Pedra: (2008-2011) primary sample, N = 120; (1999-2001) validation sample, N = 35. Parasites were genotyped by Sanger's sequencing o

SUBMITTER: Silva JA 

PROVIDER: S-EPMC9239440 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature