Appropriateness of the current parasitological control target for hookworm morbidity: A statistical analysis of individual-level data.

ABSTRACT:

Background

Soil-transmitted helminths affect almost 2 billion people globally. Hookworm species contribute to most of the related morbidity. Hookworms mainly cause anaemia, due to blood loss at the site of the attachment of the adult worms to the human intestinal mucosa. The World Health Organization (WHO) aims to eliminate hookworm morbidity by 2030 through achieving a prevalence of moderate and heavy intensity (M&HI) infections below 2%. In this paper, we aim to assess the suitability of this threshold to reflect hookworm-attributable morbidity.

Methodology/principal findings

We developed a hierarchical statistical model to simulate individual haemoglobin concentrations in association with hookworm burdens, accounting for low haemoglobin values attributable to other causes

SUBMITTER: Malizia V 

PROVIDER: S-EPMC9239476 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature