Natriuretic peptide receptor B maintains heart rate and sinoatrial node function via cyclic GMP-mediated signalling.

ABSTRACT:

Aims

Heart rate (HR) is a critical indicator of cardiac performance that is determined by sinoatrial node (SAN) function and regulation. Natriuretic peptides, including C-type NP (CNP), have been shown to modulate ion channel function in the SAN when applied exogenously. CNP is the only NP that acts as a ligand for natriuretic peptide receptor-B (NPR-B). Despite these properties, the ability of CNP and NPR-B to regulate HR and intrinsic SAN automaticity in vivo, and the mechanisms by which it does so, are incompletely understood. Thus, the objective of this study was to determine the role of NPR-B signalling in regulating HR and SAN function.

Methods and results

We have used NPR-B deficient mice (NPR-B+/-) to study HR regulation and SAN function using telemetry in conscious

SUBMITTER: Dorey TW 

PROVIDER: S-EPMC9239581 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature