A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis.

ABSTRACT: Osteoarthritis is a prevalent joint disease and a major cause of disability worldwide with no curative therapy. Development of disease-modifying therapies requires a better understanding of the molecular mechanisms underpinning disease. A hallmark of osteoarthritis is cartilage degradation. To define molecular events characterizing osteoarthritis at the whole transcriptome level, we performed deep RNA sequencing in paired samples of low- and high-osteoarthritis grade knee cartilage derived from 124 patients undergoing total joint replacement. We detected differential expression between low- and high-osteoarthritis grade articular cartilage for 365 genes and identified a 38-gene signature in osteoarthritis cartilage by replicating our findings in an independent dataset. We also found differ

SUBMITTER: Katsoula G 

PROVIDER: S-EPMC9239745 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature