Identification of Hub Genes for Early Diagnosis and Predicting Prognosis in Colon Adenocarcinoma.

ABSTRACT: Colon adenocarcinoma (COAD) is among the most common digestive system malignancies worldwide, and its pathogenesis and gene signatures remain unclear. This study explored the genetic characteristics and molecular mechanisms underlying colon cancer development. Three gene expression data sets were obtained from the Gene Expression Omnibus (GEO) database. GEO2R was used to determine differentially expressed genes (DEGs) between COAD and normal tissues. Then, the intersection of the data sets was obtained. Metascape was used to perform the functional enrichment analyses. Next, STRING was used to build protein-protein interaction (PPI) networks. Hub genes were identified and analysed using Cytoscape. Next, survival analysis and expression analysis of the hub genes were performed. ROC curve ana

SUBMITTER: Xu S 

PROVIDER: S-EPMC9239823 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature