Health consequences of early-onset compared with late-onset type 2 diabetes mellitus.

ABSTRACT:

Background

Although cumulating evidence has suggested that early-onset type 2 diabetes mellitus (T2DM) conferred on patients a broader tendency for complications beyond vascular ones, a comprehensive analysis of patterns of complications across all relevant systems is currently lacking.

Method

We prospectively studied 1 777 early-onset (age at diagnosis ≤ 45 years) and 35 889 late-onset (>45 years) T2DM patients with matched unexposed individuals from the UK Biobank. Diabetes-specific and -related complications were examined using phenome-wide association analysis, with patterns identified by comorbidity network analysis. We also evaluated the effect of lifestyle modifications and glycemic control on complication development.

Results

The median follow-up times for ear

SUBMITTER: Hou C 

PROVIDER: S-EPMC9239845 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature