The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study.

ABSTRACT:

Background/objectives

Intranasal (IN) administration of insulin decreases appetite in humans, but the underlying mechanisms are unclear, and it is unknown whether IN insulin affects the food intake of women with obesity.

Subjects/methods

In a double-blind, placebo-controlled, crossover design, participants (35 lean women and 17 women with obesity) were randomized to receive 160 IU/1.6 mL of IN insulin or placebo in a counterbalanced order in the post prandial state. The effects of IN insulin on cookie intake, appetite, mood, food reward, cognition and neural activity were assessed.

Results

IN insulin in the post prandial state reduced cookie intake, appetite and food reward relative to placebo and these effects were more pronounced for women with obesity compared with

SUBMITTER: Schneider E 

PROVIDER: S-EPMC9239904 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature