Parental feeding and childhood genetic risk for obesity: exploring hypothetical interventions with causal inference methods.

ABSTRACT:

Background

Parental-feeding behaviors are common intervention targets for childhood obesity, but often only deliver small changes. Childhood BMI is partly driven by genetic effects, and the extent to which parental-feeding interventions can mediate child genetic liability is not known. Here we aim to examine how potential interventions on parental-feeding behaviors can mitigate some of the association between child genetic liability and BMI in early adolescence, using causal inference methods.

Methods

Data from the Avon Longitudinal Study of Parents and Children were used to estimate an interventional disparity measure for a child polygenic score for BMI (PGS-BMI) on BMI at 12 years. The approach compares counterfactual outcomes for different hypothetical interventions on pa

SUBMITTER: Herle M 

PROVIDER: S-EPMC9239906 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature