Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight.

ABSTRACT:

Background

The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight in childhood, mediated through cord blood metabolites. Additionally, rapid postnatal growth was considered a potential mediator on childhood overweight, alone and sequentially to each metabolite.

Methods

Within four European birth-cohorts (N = 375 mother-child dyads), information on seven prenatal exposures (maternal education, pre-pregnancy BMI, weight gain and tobacco smoke during pregnancy, age at delivery, parity, and child gestational age), selected as obesogenic according to a-priori knowledge, was collected. Cord blood levels of 31 metabolites, as

SUBMITTER: Alfano R 

PROVIDER: S-EPMC9239910 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature