Mitochondrial modulators for obsessive-compulsive and related disorders: a systematic review and meta-analysis.

ABSTRACT: It remains unclear whether mitochondrial modulators (MMs) are beneficial in the treatment of obsessive-compulsive and related disorders. Thus, in an attempt to answer this clinical question, we performed a systematic review and a random-effects meta-analysis of double-blind, randomized, placebo-controlled trials. The primary outcome was change in overall symptoms as measured using standardized rating scales. Other outcomes were response to treatment; improvement in anxiety-related scales scores, depression-related scale scores, Clinical Global Impression Severity Scale (CGI-S) scores, and Sheehan Disability Scale (SDS) scores; all-cause discontinuation; and individual adverse events. We calculated the standardized mean differences for continuous outcomes and risk ratios for dichotomous out

SUBMITTER: Kishi T 

PROVIDER: S-EPMC9240021 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature