M⁶A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration.

ABSTRACT: Neutrophil migration into the site of infection is necessary for antibacterial innate defense, whereas impaired neutrophil migration may result in excessive inflammation and even sepsis. The neutrophil migration directed by extracellular signals such as chemokines has been extensively studied, yet the intrinsic mechanism for determining neutrophil ability to migrate needs further investigation. N⁶-methyladenosine (m⁶A) RNA modification is important in immunity and inflammation, and our preliminary data indicate downregulation of RNA m⁶A demethylase alkB homolog 5 (ALKBH5) in neutrophils during bacterial infection. Whether m⁶A modification and ALKBH5 might intrinsically modulate neutrophil innate response remain unknown. Here we report that ALKBH5

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9240034 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature