Ontology highlight
ABSTRACT:
SUBMITTER: Tao L
PROVIDER: S-EPMC9240069 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Tao Ling L Mohammad Mahmoud A MA Milazzo Giorgio G Moreno-Smith Myrthala M Patel Tajhal D TD Zorman Barry B Badachhape Andrew A Hernandez Blanca E BE Wolf Amber B AB Zeng Zihua Z Foster Jennifer H JH Aloisi Sara S Sumazin Pavel P Zu Youli Y Hicks John J Ghaghada Ketan B KB Putluri Nagireddy N Perini Giovanni G Coarfa Cristian C Barbieri Eveline E
Nature communications 20220628 1
Neuroblastoma (NB) is a childhood cancer arising from sympatho-adrenal neural crest cells. MYCN amplification is found in half of high-risk NB patients; however, no available therapies directly target MYCN. Using multi-dimensional metabolic profiling in MYCN expression systems and primary patient tumors, we comprehensively characterized the metabolic landscape driven by MYCN in NB. MYCN amplification leads to glycerolipid accumulation by promoting fatty acid (FA) uptake and biosynthesis. We foun ...[more]