Electrospun polycaprolactone nanofibrous membranes loaded with baicalin for antibacterial wound dressing.

ABSTRACT: Due to the rise in bacterial resistance, the antibacterial extractions from Chinese herbs have been used more frequently for wound care. In this work, baicalin, an extraction from the Chinese herb Scutellaria baicalensis, was utilized as the antibacterial component in the poly(ε-caprolactone)/MXene (PCL/Ti₃C₂T_X) hybrid nanofibrous membranes for wound dressing. The results revealed that the presence of Ti₃C₂T_X aided in the diameter reduction of the electrospun nanofibers. The PCL hybrid membrane containing 3 wt% Ti₃C₂T_X nanoflakes and 5 wt% baicalin exhibited the smallest mean diameter of 210 nm. Meanwhile, the antibacterial tests demonstrated that the PCL ternary hybrid nanofibers containing

SUBMITTER: Zeng W 

PROVIDER: S-EPMC9240071 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature