A model-specific simplification of the Mouse Grimace Scale based on the pain response of intraperitoneal CCl₄ injections.

ABSTRACT: Despite its long establishment and applicability in mice pain detection, the Mouse Grimace Scale still seems to be underused in acute pain detection during chronic experiments. However, broadening its applicability can identify possible refinement approaches such as cumulative severity and habituation to painful stimuli. Therefore, this study focuses on two main aspects: First, five composite MGS criteria were evaluated with two independent methods (the MoBPs algorithm and a penalized least squares regression) and ranked for their relative importance. The most important variable was used in a second analysis to specifically evaluate the context of pain after an i.p. injection (intervention) in two treatment groups (CCl₄ and oil (control)) at fixed times throughout four weeks in

SUBMITTER: Ernst L 

PROVIDER: S-EPMC9240072 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature