Transcallosal and Corticospinal White Matter Disease and Its Association With Motor Impairment in Multiple Sclerosis.

ABSTRACT:

Purpose

In this cross-sectional, proof-of-concept study, we propose that using the more pathologically-specific neurite orientation dispersion and density imaging (NODDI) method, in conjunction with high-resolution probabilistic tractography, white matter tract templates can improve the assessment of regional axonal injury and its association with disability of people with multiple sclerosis (pwMS).

Methods

Parametric maps of the neurite density index, orientation dispersion index, and the apparent isotropic volume fraction (IVF) were estimated in 18 pwMS and nine matched healthy controls (HCs). Tract-specific values were measured in transcallosal (TC) fibers from the paracentral lobules and TC and corticospinal fibers from the ventral and dorsal premotor areas, presupplemen

SUBMITTER: Yoon K 

PROVIDER: S-EPMC9240189 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature