Primary Sclerosing Cholangitis and Inflammatory Bowel Disease: A Review.

ABSTRACT: Primary sclerosing cholangitis is a disease affecting around 0.006-0.016% of the population. Of these, around 75% have concomitant inflammatory bowel disease (IBD) according to the most recent epidemiological studies. Several theories have been proposed regarding the pathogenesis of primary sclerosing cholangitis (PSC). These include changes in the function of cholangiocytes, effects of the gut microbiome, association with specific human leukocyte antigen haplotypes and dysregulation of the immune system. However, these do not explain the observed association with IBD. Moreover, there are considerable differences in the frequency and outcomes between patients with PSC and ulcerative colitis compared with PSC and Crohn's disease. The aim of this review is to appraise the most recent studies

SUBMITTER: Da Cunha T 

PROVIDER: S-EPMC9240248 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature