The Effect of Elevated Alanine Transaminase on Non-invasive Prenatal Screening Failures.

ABSTRACT:

Objective

To determine the effects of alanine transaminase (ALT) levels on the screening failure rates or "no calls" due to low fetal fraction (FF) to obtain a result in non-invasive prenatal screening (NIPS).

Methods

NIPS by sequencing and liver enzyme measurements were performed in 7,910 pregnancies at 12-26 weeks of gestation. Univariate and multivariable regression models were used to evaluate the significant predictors of screening failure rates among maternal characteristics and relevant laboratory parameters.

Results

Of the 7,910 pregnancies that met the inclusion criteria, 134 (1.69%) had "no calls." Multiple logistic regression analysis demonstrated that increased body mass index, ALT, prealbumin, albumin levels, and in vitro fertilization (IVF) concep

SUBMITTER: Chen P 

PROVIDER: S-EPMC9240308 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature