The Genetics and Epigenetics of Ventricular Arrhythmias in Patients Without Structural Heart Disease.

ABSTRACT: Ventricular arrhythmia without structural heart disease is an arrhythmic disorder that occurs in structurally normal heart and no transient or reversible arrhythmia factors, such as electrolyte disorders and myocardial ischemia. Ventricular arrhythmias without structural heart disease can be induced by multiple factors, including genetics and environment, which involve different genetic and epigenetic regulation. Familial genetic analysis reveals that cardiac ion-channel disorder and dysfunctional calcium handling are two major causes of this type of heart disease. Genome-wide association studies have identified some genetic susceptibility loci associated with ventricular tachycardia and ventricular fibrillation, yet relatively few loci associated with no structural heart disease. The effe

SUBMITTER: Wang M 

PROVIDER: S-EPMC9240357 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature