Altered Regional Brain Glucose Metabolism in Diffuse Large B-Cell Lymphoma Patients Treated With Cyclophosphamide, Epirubicin, Vincristine, and Prednisone: An Fluorodeoxyglucose Positron Emission Tomography Study of 205 Cases.

ABSTRACT:

Background

A growing number of neuroimaging studies reported that chemotherapy might impair brain functions, leading to persistent cognitive alterations in a subset of cancer patients. The present study aimed to investigate the regional brain glucose metabolism differences between diffuse large B cell lymphoma (DLBCL) patients treated with cyclophosphamide, epirubicin, vincristine, and prednisone and controls using positron emission tomography with ¹⁸F-labeled fluoro-2-deoxyglucose integrated with computed tomography (¹⁸F-FDG PET/CT) scanning.

Methods

We analyzed ¹⁸F-FDG PET data from 205 right-handed subjects (for avoiding the influence of handedness factors on brain function), including 105 post-chemotherapy DLBCL patients and 100 controls.

SUBMITTER: Hu Y 

PROVIDER: S-EPMC9240384 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature