Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis.

ABSTRACT: Pro-inflammatory immune system development, metabolomic defects, and deregulation of autophagy play interconnected roles in driving the pathogenesis of systemic lupus erythematosus (SLE). Lupus nephritis (LN) is a leading cause of morbidity and mortality in SLE. While the causes of SLE have not been clearly delineated, skewing of T and B cell differentiation, activation of antigen-presenting cells, production of antinuclear autoantibodies and pro-inflammatory cytokines are known to contribute to disease development. Underlying this process are defects in autophagy and mitophagy that cause the accumulation of oxidative stress-generating mitochondria which promote necrotic cell death. Autophagy is generally inhibited by the activation of the mammalian target of rapamycin (mTOR), a large prot

SUBMITTER: Caza T 

PROVIDER: S-EPMC9240418 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature