Discovery of Drug Candidates for Specific Human Disease Based on Natural Products of Gut Microbes.

ABSTRACT: The beneficial metabolites of the microbiome could be used as a tool for screening drugs that have the potential for the therapy of various human diseases. Narrowing down the range of beneficial metabolite candidates in specific diseases was primarily a key step for further validation in model organisms. Herein, we proposed a reasonable hypothesis that the metabolites existing commonly in multiple beneficial (or negatively associated) bacteria might have a high probability of being effective drug candidates for specific diseases. According to this hypothesis, we screened metabolites associated with seven human diseases. For type I diabetes, 45 out of 88 screened metabolites had been reported as potential drugs in the literature. Meanwhile, 18 of these metabolites were specific to type I di

SUBMITTER: Wang CY 

PROVIDER: S-EPMC9240467 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature