Plasma Exosome miRNAs Profile in Patients With ST-Segment Elevation Myocardial Infarction.

ABSTRACT:

Background

Circulating microRNAs (miRNAs) have been found to have different expressions in different phases of acute myocardial infarction. The profiles of plasma exosome miRNAs in patients with ST-segment elevation myocardial infarction (STEMI) at 3-6 months postinfarction are unknown.

Objective

The aim of this study was to assess the profiles of plasma exosome miRNAs in patients with STEMI in comparison with healthy volunteers and to select specific exosome miRNAs related to pathophysiological changes post-STEMI.

Methods

Plasma and echocardiography parameters were collected from 30 patients 3-6 months after STEMI and 30 healthy volunteers. Plasma exosome miRNAs were assessed by using high-throughput sequence (Illumina HiSeq 2500) and profile of the plasma exosome mi

SUBMITTER: Guan R 

PROVIDER: S-EPMC9240753 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature