Domain-specific cognitive course in schizophrenia: Group- and individual-level changes over 10 years.

ABSTRACT: Cognitive impairments in schizophrenia are well-documented, present across several cognitive domains and found to be relatively stable over time. However, there is a high degree of heterogeneity and indications of domain-specific developmental courses. The present study investigated the 10-year cognitive course in participants with first-episode schizophrenia (FES) and healthy controls on eight cognitive domains and a composite score, looking at group- and individual-level changes. A total of 75 FES participants and 91 healthy controls underwent cognitive assessment at baseline and follow-up. Linear mixed models were used for group-level analyses and reliable change index (RCI) analyses were used to investigate individual change. The prevalence of clinically significant impairment was expl

SUBMITTER: Flaaten CB 

PROVIDER: S-EPMC9240854 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature