Identifying key signs of motor neurone disease in primary care: a nested case-control study using the QResearch database.

ABSTRACT:

Objective

To confirm the symptoms and signs for motor neuron disease (MND) in the Red Flag tool; to quantify the extent to which the key symptoms and signs are associated with MND; and to identify additional factors which may be helpful within the primary care setting in recognition of possible MND and triggering timely referral to neurology specialists.

Design

A nested case-control study.

Setting

1292 UK general practices contributing to the QResearch primary care database, linked to hospital and mortality data.

Participants

Baseline cohort included 16.8 million individuals aged 18 years and over without a diagnosis of MND at study entry and with more than 3 years of digitalised information available. The nested case-control data set comprised of 6437 cases of

SUBMITTER: Mei XW 

PROVIDER: S-EPMC9240876 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature