Mechanistic study of the solubilization effect of basic amino acids on a poorly water-soluble drug.

ABSTRACT: Amino acids have shown promising abilities to form complexes with poorly water-soluble drugs and improve their physicochemical properties for a better dissolution profile through molecular interactions. Salt formation via ionization between acidic drugs and basic amino acids is known as the major contributor to solubility enhancement. However, the mechanism of solubility enhancement due to non-ionic interactions, which is less pH-dependent, remains unclear. The aim of this study is to evaluate non-ionic interactions between a model acidic drug, indomethacin (IND), and basic amino acids, arginine, lysine and histidine, in water. At low concentrations of amino acids, IND-arginine and IND-lysine complexes have shown a linear relationship (A_L-type phase solubility diagram) be

SUBMITTER: Alsalhi MS 

PROVIDER: S-EPMC9240925 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature