Donor characteristics and their impact on kidney transplantation outcomes: Results from two nationwide instrumental variable analyses based on outcomes of donor kidney pairs accepted for transplantation.

ABSTRACT:

Background

Donor-characteristics and donor characteristics-based decision algorithms are being progressively used in the decision process whether or not to accept an available donor kidney graft for transplantation. While this may improve outcomes, the performance characteristics of the algorithms remains moderate. To estimate the impact of donor factors of grafts accepted for transplantation on transplant outcomes, and to test whether implementation of donor-characteristics-based algorithms in clinical decision-making is justified, we applied an instrumental variable analysis to outcomes for kidney donor pairs transplanted in different individuals.

Methods

This analysis used (dis)congruent outcomes of kidney donor pairs as an instrument and was based on national transplanta

SUBMITTER: Schaapherder AF 

PROVIDER: S-EPMC9240982 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature