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Artificial Metalloproteins: At the Interface between Biology and Chemistry.

ABSTRACT: Artificial metalloproteins (ArMs) have recently gained significant interest due to their potential to address issues in a broad scope of applications, including biocatalysis, biotechnology, protein assembly, and model chemistry. ArMs are assembled by the incorporation of a non-native metallocofactor into a protein scaffold. This can be achieved by a number of methods that apply tools of chemical biology, computational de novo design, and synthetic chemistry. In this Perspective, we highlight select systems in the hope of demonstrating the breadth of ArM design strategies and applications and emphasize how these systems address problems that are otherwise difficult to do so with strictly biochemical or synthetic approaches.

SUBMITTER: Kerns SA

PROVIDER: S-EPMC9241007 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Artificial Metalloproteins: At the Interface between Biology and Chemistry.

Kerns Spencer A SA Biswas Ankita A Minnetian Natalie M NM Borovik A S AS

JACS Au 20220602 6

Artificial metalloproteins (ArMs) have recently gained significant interest due to their potential to address issues in a broad scope of applications, including biocatalysis, biotechnology, protein assembly, and model chemistry. ArMs are assembled by the incorporation of a non-native metallocofactor into a protein scaffold. This can be achieved by a number of methods that apply tools of chemical biology, computational <i>de novo</i> design, and synthetic chemistry. In this Perspective, we highli ...[more]

PMID: 35783165

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