Nonparametric percentile curve estimation for a nonnegative marker with excessive zeros.

ABSTRACT: Norm curves for the head circumference, height, and weight of newborns and infants are widely known examples of percentile curves over age, and early accounts date back 50 years. The advent of the Agatston score for coronary calcification based on coronary computed tomography in 1990 heralded the era of a new marker in preventive medicine, in addition to well-known cardiovascular risk factors. A peculiarity of the nonnegative Agatston score in populations that are free of coronary artery disease is the overexpression of zeros. In a case study, we have demonstrated a nonparametric approach for percentile curve estimation using markers such as the Agatston score. This method is based on lowess smoothing of marker-positive scores on age, and the resulting percentile curves are subsequently tr

SUBMITTER: Gerke O 

PROVIDER: S-EPMC9241054 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature