Placental morphology in association with autism-related traits in the EARLI study.

ABSTRACT:

Background

In prior work we observed differences in morphology features in placentas from an autism-enriched cohort as compared to those from a general population sample. Here we sought to examine whether these differences associate with ASD-related outcomes in the child.

Methods

Participants (n = 101) were drawn from the Early Autism Risk Longitudinal Investigation (EARLI), a cohort following younger siblings of children with autism spectrum disorder (ASD). ASD-related outcomes, including the Social Responsiveness Scale (SRS), Mullen Scales of Early Learning (MSEL) Early Learning Composite, and ASD diagnosis, were assessed at age 3. Crude and adjusted linear regression was used to examine associations between placental morphological features (parametrized continuously and i

SUBMITTER: Zhong C 

PROVIDER: S-EPMC9241175 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature