A nomogram based on A-to-I RNA editing predicting overall survival of patients with lung squamous carcinoma.

ABSTRACT:

Background

Adenosine-to-inosine RNA editing (ATIRE) is characterized as non-mutational epigenetic reprogramming hallmark of cancer, while little is known about its predictive role in cancer survival.

Methods

To explore survival-related ATIRE events in lung squamous cell carcinoma (LUSC), ATIRE profile, gene expression data, and corresponding clinical information of LUSC patients were downloaded from the TCGA database. Patients were randomly divided into a training (n = 134) and validation cohort (n = 94). Cox proportional hazards regression followed by least absolute shrinkage and selection operator algorithm were performed to identify survival-related ATIRE sites and to generate ATIRE risk score. Then a nomogram was constructed to predict overall survival (OS) of LUSC patie

SUBMITTER: Liu L 

PROVIDER: S-EPMC9241197 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature