Analysis of adverse drug events in pulmonary Mycobacterium avium complex disease using spontaneous reporting system.

ABSTRACT:

Background

In Japan, Mycobacterium avium complex lung disease (MAC-LD) is the most common in nontuberculous mycobacterial lung disease. Patients often experience adverse events, resulting in the discontinuation of treatment, which causes treatment failure. The JADER (Japanese Adverse Drug Event Report) database is a database of adverse events that allows us to collect real-world data on adverse events. We can collect large-scale data cost-effectively and detect signals of potential adverse events such as reporting odds ratio (ROR) by using spontaneous reporting systems. In this study, we aimed to elucidate the adverse events of clarithromycin (CAM), ethambutol (EB), and rifampicin (RFP) using the JADER database.

Methods

We included cases of MAC-LD between April 2004 and June

SUBMITTER: Ozawa T 

PROVIDER: S-EPMC9241207 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature