Effects of obesity on CC16 and their potential role in overweight/obese asthma.

ABSTRACT:

Introduction

Club cell secretory protein-16 (CC16) is a major anti-inflammatory protein expressed in the airway; however, the potential role of CC16 on overweight/obese asthma has not been assessed. In this study, we examined whether obesity reduces airway/circulatory CC16 levels using experimental and epidemiological studies. Then, we explored the mediatory role of CC16 in the relationship of overweight/obesity with clinical asthma measures.

Methods

Circulating CC16 levels were assessed by ELISA in three independent human populations, including two groups of healthy and general populations and asthma patients. The percentage of cells expressing club markers in obese vs. non-obese mice and human airways was determined by immunohistochemistry. A causal mediation analysis was

SUBMITTER: Goudarzi H 

PROVIDER: S-EPMC9241210 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature