Helminth antigens differentially modulate the activation of CD4⁺ and CD8⁺ T lymphocytes of convalescent COVID-19 patients in vitro.

ABSTRACT:

Background

The coronavirus disease 2019 (COVID-19) is a respiratory disease caused by SARS-CoV-2, a recently discovered strain of coronavirus. The virus has spread rapidly, causing millions of death worldwide. Contrary to the predictions, prevalence and mortality due to COVID-19 have remained moderate on the African continent. Several factors, including age, genetics, vaccines, and co-infections, might impact the course of the pandemic in Africa. Helminths are highly endemic in Sub-Saharan Africa and are renowned for their ability to evade, skew, and suppress human immune responses through various immune-modulatory mechanisms. Such effects will likely impact SARS-CoV-2 transmission and disease progression.

Methods

Here, we analyzed in vitro the impact of antigen extracts fro

SUBMITTER: Adjobimey T 

PROVIDER: S-EPMC9241220 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature