Hyb4mC: a hybrid DNA2vec-based model for DNA N4-methylcytosine sites prediction.

ABSTRACT:

Background

DNA N4-methylcytosine is part of the restrictive modification system, which works by regulating some biological processes, for example, the initiation of DNA replication, mismatch repair and inactivation of transposon. However, using experimental methods to detect 4mC sites is time-consuming and expensive. Besides, considering the huge differences in the number of 4mC samples among different species, it is challenging to achieve a robust multi-species 4mC site prediction performance. Hence, it is of great significance to develop effective computational tools to identify 4mC sites.

Results

This work proposes a flexible deep learning-based framework to predict 4mC sites, called Hyb4mC. Hyb4mC adopts the DNA2vec method for sequence embedding, which captures more effi

SUBMITTER: Liang Y 

PROVIDER: S-EPMC9241225 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature