Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations.

ABSTRACT:

Background

Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and environmental risk factors that disproportionately afflicts communities of color. Leveraging existing large-scale genome-wide association studies (GWAS), polygenic risk scores (PRS) have shown promise to complement established clinical risk factors and intervention paradigms, and improve early diagnosis and prevention of T2D. However, to date, T2D PRS have been most widely developed and validated in individuals of European descent. Comprehensive assessment of T2D PRS in non-European populations is critical for equitable deployment of PRS to clinical practice that benefits global populations.

Methods

We integrated T2D GWAS in European, African, and East Asian populations to construct a trans-an

SUBMITTER: Ge T 

PROVIDER: S-EPMC9241245 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature