Switching to ziv-aflibercept in resistant diabetic macular edema non responsive to ranibizumab injection.

ABSTRACT:

Background

Diabetic macular edema (DME) is a leading cause of visual loss in diabetic patients and is managed using multiple anti-vascular endothelial growth factor (VEGF) agents such as bevacizumab, ranibizumab and aflibercept. The present study evaluates effectiveness of intravitreal injection of ziv-aflibercept in resistant diabetic macular edema.

Methods

This is a prospective interventional study that was carried out on 59 eyes of 40 diabetic patients with diabetic macular edema resistant to three prior consecutive ranibizumab injections. On all patients, thorough ophthalmic evaluation including optical coherence tomography was performed. In patients with persistent intraretinal or subretinal fluid, ziv- aflibercept 1.25 mg (0.05 ml) was administered by intravitreal inje

SUBMITTER: Nawar AE 

PROVIDER: S-EPMC9241277 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature