Muse cells decrease the neuroinflammatory response by modulating the proportion of M1 and M2 microglia in vitro.

ABSTRACT: Neuroinflammation hinders repair of the central nervous system (CNS). Stem cell transplantation is a very promising approach for treatment of CNS injuries. However, it is difficult to select seed cells that can both facilitate nerve regeneration and improve the microenvironment in the CNS. In this study, we isolated multilineage-differentiating stress-enduring (Muse) cells from bone marrow mesenchymal stem cells. We explored the anti-inflammatory effect and mechanism of Muse cells in vitro by coculture of Muse cells with lipopolysaccharide-stimulated microglia. Our results showed that Muse cells effectively reduced the transcription and secretion of tumor necrosis factor α and interleukin-1β and increased the expression of transforming growth factor-β and interleukin-10 in microglia. In ad

SUBMITTER: Yin XY 

PROVIDER: S-EPMC9241390 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature