Transcriptional Response of Candida auris to the Mrr1 Inducers Methylglyoxal and Benomyl.

ABSTRACT: Candida auris is an urgent threat to human health due to its rapid spread in health care settings and its repeated development of multidrug resistance. Diseases that increase risk for C. auris infection, such as diabetes, kidney failure, or immunocompromising conditions, are associated with elevated levels of methylglyoxal (MG), a reactive dicarbonyl compound derived from several metabolic processes. In other Candida species, expression of MG reductase enzymes that catabolize and detoxify MG are controlled by Mrr1, a multidrug resistance-associated transcription factor, and MG induces Mrr1 activity. Here, we used transcriptomics and genetic assays to determine that C. auris MRR1a contributes to MG resistance, and that the main Mrr1a targets are an MG reductase and MDR1

SUBMITTER: Biermann AR 

PROVIDER: S-EPMC9241502 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature