Sputum Metabolites Associated with Nontuberculous Mycobacterial Infection in Cystic Fibrosis.

ABSTRACT: Nontuberculous mycobacterial (NTM) pulmonary infections in people with cystic fibrosis (CF) are associated with significant morbidity and mortality and are increasing in prevalence. Host risk factors for NTM infection in CF are largely unknown. We hypothesize that the airway microbiota represents a host risk factor for NTM infection. In this study, 69 sputum samples were collected from 59 people with CF; 42 samples from 32 subjects with NTM infection (14 samples collected before incident NTM infection and 28 samples collected following incident NTM infection) were compared to 27 samples from 27 subjects without NTM infection. Sputum samples were analyzed with 16S rRNA gene sequencing and metabolomics. A supervised classification and correlation analysis framework (sparse partial least-squa

SUBMITTER: Breen P 

PROVIDER: S-EPMC9241540 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature