Randomized controlled trial of once-per-week intermittent fasting for health improvement: the WONDERFUL trial.

ABSTRACT:

Aims

Low-density lipoprotein cholesterol (LDL-C) predicts heart disease onset and may be reduced by intermittent fasting. Some studies, though, reported that fasting increased LDL-C; however, no study evaluated LDL-C as the primary endpoint. This randomized controlled trial evaluated the effect of low-frequency intermittent fasting on LDL-C and other biomarkers.

Methods and results

Adults aged 21-70 years were enrolled who were not taking a statin, had modestly elevated LDL-C, had ≥1 metabolic syndrome feature or type 2 diabetes, and were not taking anti-diabetic medication (N = 103). Water-only 24-h fasting was performed twice weekly for 4 weeks and then once weekly for 22 weeks; controls ate ad libitum. The primary outcome was 26-week LDL-C change score. Seco

SUBMITTER: Bartholomew CL 

PROVIDER: S-EPMC9241570 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature