Causal relation of tricuspid regurgitation for heart failure outcomes: a mediation analysis of echocardiographic predictors.

ABSTRACT:

Aims

Although significant tricuspid regurgitation (TR) is critically associated with heart failure (HF) prognosis, the predictors for large TR impact on HF outcomes remain unknown. This study aimed to identify echocardiographic predictors for a causal relation of TR to HF outcomes.

Methods and results

In a retrospective, acute HF cohort of 462 patients, multivariate logistic regression analysis was performed to determine subgroups with strong association of greater-than-moderate TR with HF readmission or cardiovascular death in a year. We then conducted causal mediation analysis according to persistent atrial fibrillation (Af) or mitral regurgitation (MR) to identify the echocardiographic predictors. The association of TR with HF outcomes was prominent in subgroups of female

SUBMITTER: Hakuno D 

PROVIDER: S-EPMC9241574 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature