Coexistence of tmexCD-toprJ, bla_NDM-1, and bla_IMP-4 in One Plasmid Carried by Clinical Klebsiella spp.

ABSTRACT: In clinical practice, carbapenems and tigecycline are considered significant options for treating infections caused by multidrug-resistant Klebsiella spp. The continual evolution of resistance mechanisms to carbapenems and tigecycline is shattering the present condition. Meanwhile, convergence of the two resistance mechanisms in a single strain has been reported repeatedly, posing a significant threat to public health and safety. In this study, two carbapenem- and tigecycline-resistant Klebsiella species were obtained from patients and investigated using antimicrobial susceptibility testing, conjugation assay, whole-genome sequencing, and bioinformatics analysis. In Klebsiella variicola FK2020ZBJ35, an untransferable multidrug IncFIB(Mar)/IncHI1B-like plasmid carrying tmex

SUBMITTER: Xiao T 

PROVIDER: S-EPMC9241619 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature