Within-Host Genetic Variation in Neisseria gonorrhoeae over the Course of Infection.

ABSTRACT: Knowledge of within-host genetic variation informs studies on transmission dynamics. We studied within-host genetic variation in Neisseria gonorrhoeae over the course of infection and across different anatomical locations. Isolates were obtained during a clinical trial, and isolates from consecutive time points reflected persistent infections after treatment failure. We compared sequence types (STs) and recombination unfiltered- and filtered core genome single nucleotide polymorphism (SNP) distances in 65 within-host isolate pairs from the same anatomical location over time-obtained with a median interval of 7 days-and 65 isolate pairs across different anatomical locations at one time point. Isolates with different Multi-Locus Sequence Types (MLST), NG-Sequence Types for Antimicrobial Resi

SUBMITTER: de Korne-Elenbaas J 

PROVIDER: S-EPMC9241688 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature