Amplification of the Chromosomal bla_CTX-M-14 Gene in Escherichia coli Expanding the Spectrum of Resistance under Antimicrobial Pressure.

ABSTRACT: Various forms of adaptive evolution occur in clinical isolates in response to the presence of antimicrobial drugs. Among a total of 171 CTX-M-9 group/family extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli blood isolates recovered between 2016 and 2017 in six general hospitals, 50.3% of the isolates possessed the bla_{CTX-M-14-like} gene in their chromosome rather than in a plasmid. Focusing on this unprecedented way of the bla_CTX-M ESBL gene possession, molecular epidemiology of the isolates was assessed and the chromosomal location of the acquired cephalosporinase gene was dissected in an evolutionary point of view. Taking advantage of a complete collection of E. coli blood isolates from a limited period, clonal relatedness of the E. col

SUBMITTER: Yoon EJ 

PROVIDER: S-EPMC9241692 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature