Raffinose Inhibits Streptococcus mutans Biofilm Formation by Targeting Glucosyltransferase.

ABSTRACT: Streptococcus mutans is a representative biofilm-forming bacterium that causes dental caries through glucosyltransferase (GTF) activity. Glucans are synthesized from sucrose by GTFs and provide binding sites for S. mutans to adhere tightly to the tooth enamel. Therefore, if a novel compound that interferes with GTF function is developed, biofilm formation control in S. mutans would be possible. We discovered that raffinose, an oligosaccharide from natural products, strongly inhibited biofilm formation, GTF-related gene expression, and glucan production. Furthermore, biofilm inhibition on saliva-coated hydroxyapatite discs through the reduction of bacterial adhesion indicated the applicability of raffinose in oral health. These effects of raffinose appear to be due to its ability to modulat

SUBMITTER: Ham SY 

PROVIDER: S-EPMC9241737 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature