Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India.

ABSTRACT: Current knowledge on resistance-conferring determinants in Mycobacterium tuberculosis is biased toward globally dominant lineages 2 and 4. In contrast, lineages 1 and 3 are predominant in India. In this study, we performed whole-genome sequencing of 498 MDR M. tuberculosis isolates from India to determine the prevalence of drug resistance mutations and to understand the genomic diversity. A retrospective collection of 498 M. tuberculosis isolates submitted to the National Institute for Research in Tuberculosis for phenotypic susceptibility testing between 2014 to 2016 were sequenced. Genotypic resistance prediction was performed using known resistance-conferring determinants. Genotypic and phenotypic results for 12 antituberculosis drugs were compared, and sequence data were explored to ch

SUBMITTER: Shanmugam SK 

PROVIDER: S-EPMC9241780 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature