Optoception: Perception of Optogenetic Brain Perturbations.

ABSTRACT: How do animals experience brain manipulations? Optogenetics has allowed us to manipulate selectively and interrogate neural circuits underlying brain function in health and disease. However, little is known about whether mice can detect and learn from arbitrary optogenetic perturbations from a wide range of brain regions to guide behavior. To address this issue, mice were trained to report optogenetic brain perturbations to obtain rewards and avoid punishments. Here, we found that mice can perceive optogenetic manipulations regardless of the perturbed brain area, rewarding effects, or the stimulation of glutamatergic, GABAergic, and dopaminergic cell types. We named this phenomenon optoception, a perceptible signal internally generated from perturbing the brain, as occurs with interoceptio

SUBMITTER: Luis-Islas J 

PROVIDER: S-EPMC9241931 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature