Pre-eclampsia is associated with increased neurodevelopmental disorders in children with congenital heart disease.

ABSTRACT:

Aims

Our primary aim was to examine whether exposure to pre-eclampsia increases the risk of neurodevelopmental disorders in children born with congenital heart disease (CHD). Our secondary aim was to evaluate whether CHD and pre-eclampsia may act in synergy and potentiate this risk.

Method and results

Using population-based registries, we included all Danish children born with CHD between 1994 and 2017. Non-singletons and children born with a syndrome were excluded. Neurodevelopmental disorders including attention-deficit/hyperactivity disorder, autism spectrum disorders, and tic disorders were identified with the use of the 10th edition of International Classification of Disease (ICD-10) codes DF80-DF98. Using Cox proportional hazard regression, we estimated the risk of neu

SUBMITTER: Omann C 

PROVIDER: S-EPMC9242033 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature