High-intensity statin treatment is associated with reduced plaque structural stress and remodelling of artery geometry and plaque architecture.

ABSTRACT:

Aims

Plaque structural stress (PSS) is a major cause of atherosclerotic plaque rupture and major adverse cardiovascular events (MACE). We examined the predictors of changes in peak and mean PSS (ΔPSS_peak, ΔPSS_mean) in three studies of patients receiving either standard medical or high-intensity statin (HIS) treatment.

Methods and results

We examined changes in PSS, plaque size, and composition between 7348 co-registered baseline and follow-up virtual-histology intravascular ultrasound images in patients receiving standard medical treatment (controls, n = 18) or HIS (atorvastatin 80 mg, n = 20, or rosuvastatin 40 mg, n = 22). The relationship between changes in PSS_peak and plaque burden (PB) differed significantly between

SUBMITTER: Gu SZ 

PROVIDER: S-EPMC9242039 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature